Suzanne T. Ildstad, M.D.
Intro | Research Interests | Biosketch | Selected Publications | Staff | Protocols |

email: stild01@gwise.louisville.edu office phone 502-852-2080 FAX 502-852-2085 University of Louisville 570 S. Preston St., Baxter Bldg. Suite 404 Louisville KY 40202

Jewish Hospital Distinguished Professor of Transplantation
Professor of Surgery
Director, Institute for Cellular Therapeutics

Summary of Research Projects:

• Characterization of the Facilitating Cell
  Facilitating cells enable the long-term, durable engraftment of hematopoietic stem cells across genetic barriers. How do these unique cells function, and what is their ontogeny?
• The Sensitized State
  Sensitized recipients are more prone to bone marrow and solid organ graft rejection. Mixed chimerism may reverse the immunologic memory and establish donor specific tolerance.
• Partial Conditioning and Recipient Space
  We are working to develop partial (and therefore, less toxic) conditioning strategies for the establishment of mixed chimerism. What are the cells in the recipient "space," or microenvironment, that prevent engraftment, and how can we best target these cells?
• Diabetes and Autoimmunity
  Through the use of a non-obese diabetic mouse model, we are working to establish mixed chimerism as a means of reducing the risks associated with bone marrow transplantation for the treatment of autoimmune diseases.

Science from Bench to Bedside