Research interests:
- The mechanism of facilitating cells-mediated tolerance induction
- Diabetes-pathogenesis and/or preventing
- The role of bone marrow-derived cells in pancreatic beta cell regeneration
Professional Bio
2007-Present Assistant Professor, Dept of Physiology & Biophysics, University of Louisville, KY
2003-2007 Research Immunologist, Institute for Cellular Therapeutics, University of Louisville, KY
1999-2003 Research Fellow, Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
1997-1999 Research Fellow, Institute for Cellular Therapeutics, Allegheny University of the Health Sciences, Philadelphia, PA
1994-1996 Research Fellow, Dept. of Immunology, University of Toronto, Canada
1991-1997 Physician in Charge, Dept. of Internal Medicine, Beijing Hospital, Beijing, China
1985-1990 Resident, Dept. of Internal Medicine, Beijing Hospital, Beijing, China
Publications
Rezzoug F, Huang Y, Tanner MK, Wysoczynski M, Schanie CL, Chilton PM, Ratajczak MZ, Fugier-Vivier IJ, Ildstad ST.
TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function.
J Immunol. 2008 Jan 1;180(1):49-57.
http://www.ncbi.nlm.nih.gov/sites/entrez/18097003
Adamson LA, Huang WC, Breidenbach WC, Rahhal D, Xu H, Huang Y, Pidwell DJ, Wei FC, Tobin G, Ildstad ST.
A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts.
Microsurgery. 2007;27(7):630-6.
http://www.ncbi.nlm.nih.gov/sites/entrez/17868137
Xu H, Yan J, Huang Y, Chilton PM, Ding C, Schanie CL, Wang L, Ildstad ST.
Co-stimulatory blockade of CD154:CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization.
Blood. 2007 Sep 7; [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/sites/entrez/17827394
Xu H, Chilton PM, Huang Y, Schanie CL, Yan J, Ildstad ST.
Addition of cyclophosphamide to T-cell depletion-based nonmyeloablative conditioning allows donor T-cell engraftment and clonal deletion of alloreactive host T-cells after bone marrow transplantation.
Transplantation. 2007 Apr 15;83(7):954-63.
http://www.ncbi.nlm.nih.gov/sites/entrez/17460568
Xu H, Chilton PM, Tanner MK, Huang Y, Schanie CL, Dy-Liacco M, Yan J, Ildstad ST.
Humoral immunity is the dominant barrier for allogeneic bone marrow engraftment in sensitized recipients.
Blood. 2006 Nov 15;108(10):3611-9. Epub 2006 Aug 3.
http://www.ncbi.nlm.nih.gov/sites/entrez/16888094
Huang Y, Kucia M, Rezzoug F, Ratajczak J, Tanner MK, Ratajczak MZ, Schanie CL, Xu H, Fugier-Vivier I, Ildstad ST.
Flt3-ligand-mobilized peripheral blood, but not Flt3-ligand-expanded bone marrow, facilitating cells promote establishment of chimerism and tolerance.
Stem Cells. 2006 Apr;24(4):936-48.
http://www.ncbi.nlm.nih.gov/sites/entrez/16644924
Dawn B, Guo Y, Rezazadeh A, Huang Y, Stein AB, Hunt G, Tiwari S, Varma J, Gu Y, Prabhu SD, Kajstura J, Anversa P, Ildstad ST, Bolli R.
Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function.
Circ Res. 2006 Apr 28;98(8):1098-105. Epub 2006 Mar 23.
http://www.ncbi.nlm.nih.gov/sites/entrez/16556872
Huang Y, Rezzoug F, Xu H, Chilton PM, Schanie CL, Fugier-Vivier I, Ildstad ST.
NK cells play a critical role in the regulation of class I-deficient hemopoietic stem cell engraftment: evidence for NK tolerance correlates with receptor editing.
J Immunol. 2005 Sep 15;175(6):3753-61.
http://www.ncbi.nlm.nih.gov/sites/entrez/16148121
Fugier-Vivier IJ, Rezzoug F, Huang Y, Graul-Layman AJ, Schanie CL, Xu H, Chilton PM, Ildstad ST.
Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment.
J Exp Med. 2005 Feb 7;201(3):373-83.
http://www.ncbi.nlm.nih.gov/sites/entrez/15699072
Chilton PM, Rezzoug F, Ratajczak MZ, Fugier-Vivier I, Ratajczak J, Kucia M, Huang Y, Tanner MK, Ildstad ST.
Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients.
Blood. 2005 Mar 1;105(5):2189-97. Epub 2004 Nov 2.
http://www.ncbi.nlm.nih.gov/sites/entrez/15522953
Grimes HL, Schanie CL, Huang Y, Cramer D, Rezzoug F, Fugier-Vivier I, Ildstad ST.
Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes.
Exp Hematol. 2004 Oct;32(10):946-54.
http://www.ncbi.nlm.nih.gov/sites/entrez/15504550
Colson YL, Xu H, Huang Y, Ildstad ST.
Mixed xenogeneic chimerism induces donor-specific humoral and cellular immune tolerance for cardiac xenografts.
J Immunol. 2004 Nov 1;173(9):5827-34.
http://www.ncbi.nlm.nih.gov/sites/entrez/15494536
Chilton PM, Rezzoug F, Fugier-Vivier I, Weeter LA, Xu H, Huang Y, Ray MB, Ildstad ST.
Flt3-ligand treatment prevents diabetes in NOD mice.
Diabetes. 2004 Aug;53(8):1995-2002.
http://www.ncbi.nlm.nih.gov/sites/entrez/15277378
Huang Y, Rezzoug F, Chilton PM, Grimes HL, Cramer DE, Ildstad ST.
Matching at the MHC class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: a role for host NK cells in regulating HSC engraftment.
Blood. 2004 Aug 1;104(3):873-80. Epub 2004 Mar 30.
http://www.ncbi.nlm.nih.gov/sites/entrez/15054040
Xu H, Chilton PM, Huang Y, Schanie CL, Ildstad ST.
Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism.
J Immunol. 2004 Feb 1;172(3):1463-71.
http://www.ncbi.nlm.nih.gov/sites/entrez/14734723
Mueller YM, Cramer DE, Huang Y, Exner BG, Ildstad ST.
Hematopoietic stem cells from the marrow of mice treated with Flt3 ligand are significantly expanded but exhibit reduced engraftment potential.
Transplantation. 2002 Apr 27;73(8):1177-85.
http://www.ncbi.nlm.nih.gov/sites/entrez/11981407
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